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  • Title: Synthesis and activity of dipeptides containing epsilon-aminocaproic acid.
    Author: Midura-Nowaczek K, Bruzgo I, Roszkowska-Jakimiec W, Worowski K.
    Journal: Acta Pol Pharm; 1994; 51(6):499-504. PubMed ID: 7762400.
    Abstract:
    Five new dipeptides containing epsilon-aminocaproic acid were synthesized. All dipeptides markedly inhibit fibrinolytic activity of plasmin but only in low concentration (0.0002M). In higher concentration fibrinolytic activity was observed. Activity of dipeptides containing epsilon-aminocaproic acid, which antifibrinolytic activity is known, was tested on plasmin, thrombin, urokinase and euglobulin fraction using synthetic substrates.
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