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  • Title: Flunitrazepam for sleep disturbance in children with intractable epilepsy.
    Author: Konishi T, Masuko K, Naganuma Y, Hongou K, Yagi S.
    Journal: Brain Dev; 1995; 17(1):69-72. PubMed ID: 7762768.
    Abstract:
    Add-on therapy with flunitrazepam (FNZ) was performed in 5 children with marked sleep disturbance and intractable seizures. Correction of the sleep disturbance was attained immediately after the start of FNZ administration in all patients. Furthermore, a significant decrease in the seizure frequency (3 patients) and improved quality of life (4 patients) were concomitantly observed. There was no adverse effect or interaction with conventional AEDs on long-term use.
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