These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Peroxynitrite causes DNA nicks in plasmid pBR322.
    Author: Salgo MG, Stone K, Squadrito GL, Battista JR, Pryor WA.
    Journal: Biochem Biophys Res Commun; 1995 May 25; 210(3):1025-30. PubMed ID: 7763229.
    Abstract:
    Peroxynitrite causes single-strand breaks in pBR322 supercoiled DNA as evidenced by agarose gel electrophoresis analysis. The effect of three free radical scavengers, namely mannitol, benzoate and dimethylsulfoxide, were studied. Mannitol failed to protect DNA from damage by peroxynitrite while benzoate and dimethylsulfoxide amplified the damage. These results suggest the damage caused by peroxynitrite alone is not mediated by free radicals since typical free radical scavengers fail to prevent the damage.
    [Abstract] [Full Text] [Related] [New Search]