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  • Title: Large-scale cultivation of Catharanthus roseus cells: production of ajmalicine in a 20-l airlift bioreactor.
    Author: Fulzele DP, Heble MR.
    Journal: J Biotechnol; 1994 Jun 15; 35(1):1-7. PubMed ID: 7765026.
    Abstract:
    Bioreactor systems have been developed for the production of ajmalicine, an alkaloid used in the treatment of hypertension. Cell cultures of Catharanthus roseus produced higher levels of ajmalicine (323 micrograms g-1 dry weight) in a production medium enriched with tryptophan. The cell cultures were grown in medium prepared in tap water and market sugar with a view to minimise the costs of production. Large-scale cultivation of cell suspension was performed in a 20-l airlift bioreactor under controlled conditions. An ajmalicine production of 315 micrograms g-1 dry weight was achieved in the bioreactor after 14 d of cultivation.
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