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  • Title: Metabolic engineering for production of beta-carotene and lycopene in Saccharomyces cerevisiae.
    Author: Yamano S, Ishii T, Nakagawa M, Ikenaga H, Misawa N.
    Journal: Biosci Biotechnol Biochem; 1994 Jun; 58(6):1112-4. PubMed ID: 7765036.
    Abstract:
    We have engineered a conventional yeast, Saccharomyces cerevisiae, to confer a novel biosynthetic pathway for the production of beta-carotene and lycopene by introducing the bacterial carotenoid biosynthesis genes, which are individually surrounded by the promoters and terminators derived from S. cerevisiae. beta-Carotene and lycopene accumulated in the cells of this yeast, which was considered to be a result of the carbon flow for the ergosterol biosynthetic pathway being partially directed to the pathway for the carotenoid production.
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