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  • Title: Amyloid beta-peptide spin trapping. II: Evidence for decomposition of the PBN spin adduct.
    Author: Hensley K, Aksenova M, Carney JM, Harris M, Butterfield DA.
    Journal: Neuroreport; 1995 Feb 15; 6(3):493-6. PubMed ID: 7766851.
    Abstract:
    Synthetic beta-amyloid peptides (A betas) react with the spin trap phenyl-tert-butyl nitrone (PBN) to form products detectable by electron paramagnetic resonance (EPR) spectroscopy. At least two EPR-detectable products can be distinguished from the A beta/PBN reaction, and peptide toxicity towards glutamine synthetase enzyme correlates with the type of PBN reaction product observed. We have reacted synthetic A beta(25-35) peptide with [12C]- or [13C]PBN to demonstrate that the two products represent alternate pathways of spin adduct decomposition. Results indicate that the C=N bond of PBN is cleaved by A beta in what we hypothesize is a radical addition-fragmentation reaction.
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