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  • Title: Effect of probenecid on the formation and elimination kinetics of the sulphate and glucuronide conjugates of diflunisal.
    Author: Macdonald JI, Wallace SM, Herman RJ, Verbeeck RK.
    Journal: Eur J Clin Pharmacol; 1995; 47(6):519-23. PubMed ID: 7768255.
    Abstract:
    The effect of probenecid on the pharmacokinetics of diflunisal and its glucuronide and sulphate conjugates was studied in 8 healthy volunteers. Diflunisal 250 mg b.d. was administered p.o. for 15 days and its steady state pharmacokinetics was evaluated on Day 16 after the last dose (control phase). Probenecid 500 mg b.d. was co-administered throughout the entire study period in the treatment phase of the study. The steady state plasma concentration of diflunisal was significantly higher during the probenecid treatment phase as compared to the control phase (104.0 vs. 63.1 micrograms.ml-1). This was the result of a significant decrease in the plasma clearance of diflunisal from 5.8 (control) to 3.4 ml.min-1 (probenecid co-administration). The metabolite formation clearances of both glucuronides were significantly decreased by probenecid, -45% and -54% for the phenolic and acyl glucuronide, respectively. The metabolite formation clearance of the sulphate conjugate was not affected by probenecid coadministration. Steady state plasma concentrations of the sulphate and glucuronide conjugates of diflunisal were 2.5- to 3.1-fold higher during probenecid co-administration, due to a significant reduction in the renal clearance of the three diflunisal conjugates. Probenecid also reduced the plasma protein binding of diflunisal, but only to a minor extent; the unbound plasma fraction of diflunisal at steady state averaged between 5 and 30% higher during probenecid co-administration.
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