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  • Title: Pathological effects of MK-801 in the rat posterior cingulate/retrosplenial cortex.
    Author: Fix AS.
    Journal: Psychopharmacol Bull; 1994; 30(4):577-83. PubMed ID: 7770623.
    Abstract:
    Many N-methyl-D-aspartate (NMDA) antagonists cause vacuolization and necrosis in the posterior cingulate/retrosplenial (PC/RS) cortex of rats after single-dose administration. This article reviews a series of investigational studies that have characterized this effect. All the studies have used single doses of MK-801 in rats. Techniques employed were light microscopy, transmission electron microscopy, quantitative enzyme-linked immunosorbent assay (ELISA), and cell counting. Our studies demonstrated: (1) formation of vacuoles within 30 minutes of treatment, (2) dose-dependent necrosis of susceptible PC/RS neurons, (3) increased glial fibrillary acidic protein in response to neuronal necrosis, (4) significantly greater necrosis in female than in male rats, and (5) increases in necrosis along a rostrocaudal gradient within the PC/RS cortex. In addition, these studies illustrate a number of variables that impact the expression and detection of neuronal vacuolization and necrosis in rats after treatment with MK-801.
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