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  • Title: Effects of pineal body and melatonin on lymphocyte proliferation and dinoprostone production in rat spleen.
    Author: Ding CH, Wei W, Xu SY.
    Journal: Zhongguo Yao Li Xue Bao; 1995 Jan; 16(1):54-7. PubMed ID: 7771198.
    Abstract:
    AIM: To determine the effects of pineal body and melatonin (Mel) on lymphocyte proliferation and dinoprostone production in rat spleen. METHODS: Pinealectomy (PE), lymphocyte proliferation assay and dinoprostone radioimmunoassay were used. RESULTS: A circadian rhythm of splenic lymphocyte proliferation which peaked at 22:00 was obliterated by PE in rats. PE led to an impairment of lymphocyte proliferation and an increase of dinoprostone production, which were restored by ip Mel 10 micrograms.kg-1.d-1 at 16:00 for 7 d. Mel promoted lymphocyte proliferation and inhibited dinoprostone production in intact rats. A negative correlation between the change in lymphocyte proliferation and dinoprostone production was seen. CONCLUSION: The pineal body and its main hormone Mel play a regulatory role in circadian lymphocyte proliferation which is related to dinoprostone production in rat spleen.
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