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  • Title: [A simple method for estimating half-life of drugs obeying Michaelis-Menten elimination kinetics].
    Author: Ding Y, Huang DK, Luo JP.
    Journal: Zhongguo Yao Li Xue Bao; 1995 Jan; 16(1):65-7. PubMed ID: 7771200.
    Abstract:
    AIM: To establish a simple method for estimating half-life of drugs obeying Michaelis-Menten elimination kinetics. METHODS: A linear relationship is sketched between elimination half-life and drug concentration in blood that obey Michaelis-Menten elimination kinetics. A simple method is proposed to draw a regression line of blood drug concentration vs time after a single bolus intravenous injection. RESULTS & CONCLUSION: The elimination half-life can be read from the regression line. The method can also be used to estimate the time required for the plasma concentration of a drug to decrease any fraction.
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