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  • Title: Frontal lobe dysfunction in schizophrenia and obsessive-compulsive disorder: a neuropsychological study.
    Author: Abbruzzese M, Bellodi L, Ferri S, Scarone S.
    Journal: Brain Cogn; 1995 Mar; 27(2):202-12. PubMed ID: 7772333.
    Abstract:
    Converging evidence suggests there is a specific role of dorso-lateral-prefrontal cortex (DLPC) in schizophrenic disorders and of orbito-frontal cortex (OFC) in obsessive-compulsive disorder (OCD). Here, 25 schizophrenic and 25 OCD patients were evaluated with Wisconsin Card Sorting Test and Object Alternation Test; neuropsychological tools sensitive to DLPC and OFC damage, respectively; and compared with 25 subjects of a control group. Moreover, they all underwent Weigl's Sorting Test and the Word Fluency Test to assess global frontal functioning. The results indicated a DLPC deficit in schizophrenia and an OFC involvement in OCD. These data suggest that functional disorders of the central nervous system can be explored with neuropsychological instruments.
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