These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of iontophoretic patterns on in vivo antidiuretic response to desmopressin acetate administered transdermally.
    Author: Nakakura M, Terajima M, Kato Y, Hayakawa E, Ito K, Kuroda T.
    Journal: J Drug Target; 1995; 2(6):487-92. PubMed ID: 7773610.
    Abstract:
    The effects of concentration, amperage and duration on the antidiuretic response induced by iontophoretic delivery of desmopressin acetate (DDAVP) were examined using a diabetes insipidus model in rats. A higher current density brought about a larger and longer antidiuretic response. Prolonged iontophoretic duration caused an overdose. Repeated short iontophoretic treatments with lower current density maintained a constant response with a short lag time and a rapid disappearance of pharmacological response immediately after cessation of the final treatment. This type of iontophoresis substantially reduced the inter-subject variability of response as compared to the response using an intranasal route of administration.
    [Abstract] [Full Text] [Related] [New Search]