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  • Title: Platelet activation in patients with chronic pulmonary heart disease. Effect of dipyridamole treatment.
    Author: Zhang X, Ling P.
    Journal: Chin Med J (Engl); 1995 Feb; 108(2):95-7. PubMed ID: 7774397.
    Abstract:
    Plasma levels of beta-thromboglobulin (beta-TG), platelet factor 4(PF4) and platelet aggregation rate (PAR) were measured in remission phase of 15 patients affected with chronic pulmonary heart disease (CPHD). beta-TG, beta-TG/PF4, PF4 and PAR were significantly higher in the patients than in controls (P < 0.01 and 0.05, respectively). After 10 days of treatment with Dipyridamole 100mg tid, beta-TG, beta-TG/PF4 and PF4 decreased significantly compared with pretreatment values (P < 0.01 and 0.05, respectively). The results suggest that in vivo platelet activation is indeed present in patients with CPHD and that dipyridamole can antagonize platelet activation in vivo.
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