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  • Title: Amylin and epinephrine have no direct effect on glucose transport in isolated rat soleus muscle.
    Author: Pittner RA, Wolfe-Lopez D, Young AA, Rink TJ.
    Journal: FEBS Lett; 1995 May 22; 365(1):98-100. PubMed ID: 7774725.
    Abstract:
    Amylin and epinephrine did not significantly affect insulin stimulated, or basal, 3-O-methylglucose transport in isolated rat soleus muscle, as measured by the release of 3-O-methylglucose from pre-loaded tissue. Both amylin and epinephrine inhibited insulin-stimulated 2-deoxyglucose uptake (by 25% and 38%, respectively) in soleus muscle from fed rats but not from fasted rats. The latter results are consistent with amylin and epinephrine stimulating glycogenolysis and inhibiting hexokinase activity by intracellular accumulation of glucose 6-phosphate. We conclude that amylin, like epinephrine, does not specifically inhibit glucose transporters in skeletal muscle.
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