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  • Title: Geranylgeraniol is a potent inducer of apoptosis in tumor cells.
    Author: Ohizumi H, Masuda Y, Nakajo S, Sakai I, Ohsawa S, Nakaya K.
    Journal: J Biochem; 1995 Jan; 117(1):11-3. PubMed ID: 7775375.
    Abstract:
    We screened various isoprenoids to find inducers of apoptosis for human leukemia HL-60 cells, and found that GGO (geranylgeraniol) had the most potent apoptosis-inducing activity, as judged from DNA fragmentation in HL-60 cells. The apoptosis-inducing activity of GGO is concentration- and time-dependent. DNA synthesis by HL-60 cells was selectively inhibited on treatment with GGO. Besides HL-60 cells, apoptosis was induced by GGO in various tumor cell lines, including human myeloid multipotential leukemia K562, lymphoblastic leukemia Molt3, and colon adenocarcinoma COLO320 DM.
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