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  • Title: [Neuropathology of non conventional infectious agents or prions].
    Author: Hauw JJ, Naccache PY, Seilhean D, Camilleri S, Mokhtari K, Duyckaerts C.
    Journal: Pathol Biol (Paris); 1995 Jan; 43(1):43-52. PubMed ID: 7777377.
    Abstract:
    The neuropathological diagnosis of infections by non conventional agents relies on four lesions: astrocytic gliosis (cell hypertrophy and proliferation) usually contrasting with absent mononuclear cell infiltrates (lymphocytes, monocytes-macrophages, and/or microglia) revealed by conventional techniques, and neuronal loss in the most affected areas are little specific findings. Amyloid plaques that are inconstantly found, and spongiosis of gray matter, a characteristic and very frequent finding, are most specific. PrP immunohistochemistry brings additional data. The main diagnostic difficulties are emphasized, and guidelines for Pathological studies are recalled.
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