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  • Title: Movement-related cortical potentials preceding repetitive and random-choice hand movements in Parkinson's disease.
    Author: Touge T, Werhahn KJ, Rothwell JC, Marsden CD.
    Journal: Ann Neurol; 1995 Jun; 37(6):791-9. PubMed ID: 7778853.
    Abstract:
    The movement-related cortical electroencephalographic potential was recorded from scalp electrodes in 8 patients with idiopathic Parkinson's disease studied at least 12 hours after withdrawal of their normal drug therapy, and compared with the results from a group of 8 age-matched control subjects. Two types of self-paced voluntary arm movements were examined: repetitive forward movement of a joystick, and random-choice movements of the same joystick in which subjects had to choose freely the direction in which they were to move the stick (forward, backward, left, or right). In normal subjects, the movement-related cortical potential was larger prior to random-choice movements, whereas in the patients, the amplitude was the same in both tasks. The implication is that processes involved in self-selection of movement are abnormal in Parkinson's disease. This may contribute to the difficulty that patients have in initiating voluntary movement in the absence of any external cues.
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