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  • Title: [Detection of human papillomavirus in condyloma acuminata tissues].
    Author: Shao J, Zhou M, Ye Y.
    Journal: Zhonghua Bing Li Xue Za Zhi; 1995 Feb; 24(1):46-8. PubMed ID: 7781118.
    Abstract:
    UNLABELLED: We used immunohistochemical technique, in situ hybridization and polymerase chain reaction to detect HPV capsid antigen (HPV-Ag) and HPV-DNA sequences in genital condyloma and pseudocondyloma of vulvae tissues. We also observed the relation between HPV distribution in condylomas and their histological changes. RESULTS: 71.4% of condylomas were positive for HPV-Ag with IMHC, 96.5% of condylomas were positive for HPV6/11 DNA with ISH, and 100% of condylomas were positive for HPV6/11/16/18DNA with PCR. Only 21.4% of pseudocondylomas of vulvae were positive for HPV6/11/16/18DNA with PCR. By observing the distribution of labelled HPV-Ag and HPV-DNA, we found a close relation between HPV proliferative infection and the specific changes of condylomas.
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