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  • Title: Mucosal melanoma of the nasal cavity and paranasal sinuses.
    Author: Kingdom TT, Kaplan MJ.
    Journal: Head Neck; 1995; 17(3):184-9. PubMed ID: 7782202.
    Abstract:
    BACKGROUND: Mucosal melanomas of the nasal cavity and paranasal sinuses are rare and do poorly. METHODS: Seventeen patients treated from 1981 to 1993 at a single referral center were retrospectively reviewed. RESULTS: Thirteen patients underwent surgical resection, with seven receiving postoperative radiotherapy. Eight had microscopically negative margins. The actuarial 2-year and 5-year survivals for this group of 13 were 67% (8 of 12) and 20% (2 of 10). The local recurrence rate was 85% (11 of 13) and distant metastases occurred in 31% (4 of 13) patients. In the absence of metastatic disease, resection of recurrent tumor correlated with disease-free intervals ranging from 3 months to 40 months. CONCLUSIONS: Those who received postoperative radiotherapy appeared to have done better with increased disease-free intervals and prolonged survival. Negative surgical margins were not predictive of a more favorable outcome. Surgical resection followed by postoperative radiotherapy is appropriate and resection of recurrent tumor should be considered.
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