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  • Title: Does renal impairment protect from gout?
    Author: Youssef P, Brama T, York H, Pickard P, Stewart P, McGill N.
    Journal: J Rheumatol; 1995 Mar; 22(3):494-6. PubMed ID: 7783068.
    Abstract:
    OBJECTIVE: To test whether renal impairment protects from the development of gout. METHODS: We conducted a retrospective cohort study in which 40 hyperuricemic patients (serum uric acid > 0.54 mM/l) with renal impairment (serum creatinine > 200 microM/l) and 40 equally hyperuricemic patients with normal renal function (serum creatinine < 120 microM/l) were given a telephone questionnaire eliciting a history of gout, its pattern and severity, and other features of medical and family history. RESULTS: There was no significant difference among the prevalence of gout (relative risk 1.1, confidence interval 0.73-1.67), the pattern and severity of gout, and the presence of tophi between the 2 groups. A positive family history of gout was significantly increased in the patients with gouty arthritis (p < 0.05). CONCLUSION: Renal impairment does not protect from gout. There may be a familial factor in the development of gout that is independent from the familial tendency for hyperuricemia.
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