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  • Title: The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein.
    Author: Madani A, Soulier J, Schmid M, Plichtova R, Lermé F, Gateau-Roesch O, Garnier JP, Pla M, Sigaux F, Stern MH.
    Journal: Oncogene; 1995 Jun 01; 10(11):2259-62. PubMed ID: 7784073.
    Abstract:
    An unusually small (8 kD) protein (p8MTCP-1) is coded by the putative oncogene MTCP-1 (also called c6.1B), involved in the translocation t(X;14)(q28;q11) associated with some mature T-cell proliferations. Here, we show by subcellular fractionation and by confocal microscopy that this protein is located in the mitochondria. This localization orientates toward a role of p8MTCP-1 in the mitochondrial metabolism which may be relevant for the oncogenic process.
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