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  • Title: Release of migration inhibitory factor from mouse T and B cells activated by insoluble phytomitogens.
    Author: Sugane K, Kasahara T, Shioiri-Nakano K.
    Journal: Jpn J Exp Med; 1975 Feb; 45(1):19-24. PubMed ID: 778444.
    Abstract:
    The production of macrophage migration inhibitory factor (MIF) was studied with mouse B spleen cells and with the low density subpopulation of thymus cells (T cells) stimulated by phytomitogens. MIF was released from mouse B cells when stimulated by Sepharose-PWM but was not released by Sepharose-Con A. MIF was produced by the low density subpopulation of thymus cells stimulated by Sepharose-Con A. MIF from B cells could not be distinguished from that of the low density subpopulation of thymus cells by gel filtration on Sephadex G-100 column. The molecular size of both MIF was calculated to be 45,000-55,000 dalton.
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