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  • Title: [Combination of low molecular weight heparin and non-steroidal anti-inflammatory agents].
    Author: Dahl V, Raeder J.
    Journal: Tidsskr Nor Laegeforen; 1995 May 30; 115(14):1728-30. PubMed ID: 7785032.
    Abstract:
    Non-steroidal anti-inflammatory drugs (NSAIDs) play an important part in postoperative relief of pain. Non-steroidal anti-inflammatory drugs and paracetamol should act as non-opioid basis analgesics in the postoperative period, leading to reduced need of opioid analgesia. This is beneficial, since it may reduce possible dosage-dependent side-effects of opioids such as nausea, tiredness and respiratory depression. The inhibition of prostaglandin synthesis by non-steroidal anti-inflammatory drugs also affects haemostasis, and the combination of these drugs with prophylaxis against postoperative thrombosis with heparin is controversial. We refer to a case history which illustrates this controversy. We also discuss the effect of non-steroidal anti-inflammatory drugs on pain and inflammation. Possible side-effects of these drugs and their interaction with heparin are reviewed.
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