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  • Title: [The principles for creating drug preparations of natural origin that stimulate hematopoiesis].
    Author: Gol'dberg ED, Dygaĭ AM, Agafonov VI, Aksinenko SG, Gol'dberg VE, Zhdanov VV, Litvinenko VI, Liubavina PA, Matiash MG, Novitskiĭ EV.
    Journal: Eksp Klin Farmakol; 1995; 58(1):3-7. PubMed ID: 7787691.
    Abstract:
    The paper outlines the principles in designing hemostimulators by using glycosamineglycans. Hemostimulating properties of the tested agents is likely to be primarily due to the presence of D-glucuronic acid in their structure. The homotypic mechanisms are largely responsible for all agents' effect in stimulating hemopoiesis. Thus, they all virtually activate the function of the hemopoiesis-inducing microenvironment. In addition, they directly or indirectly stimulate the processes of proliferation and differentiation of precursor cells of erythro- and granulomonocytopoiesis.
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