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  • Title: [The limitation of glucose catabolism as a factor in protection during hypoxia].
    Author: Burbello AT, Vishvtseva VV, Denisenko PP, Safonova AF, Dobrokhotova EG.
    Journal: Eksp Klin Farmakol; 1995; 58(1):49-52. PubMed ID: 7787699.
    Abstract:
    Violuric acid was first shown to have antihypoxic and antioxidative properties, to exert protective action in sodium nitrite-induced hemic hypoxia. Hepatic glucose and glucogen levels increased, the activity of glucose-6- phosphodihydrogenase enhanced, while that of lactate dehydrogenase and alkaline phosphatase decreased, the content of cAMP restored, whereas cGMP and 2,3-diphosphoglycerate levels decreased to a greater extent. The action of violuric acid was especially evident at the ultrastructural level-the ultrastructure of brush receptor elements in anoxia in the presence of violuric acid's action retained all the features characteristic for intact animals, which was accompanied by a significant accumulation of glycogen in the neuroplasm.
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