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  • Title: Neonatal pancreatic beta-cell hyperplasia: report of a case with failure of diazoxide and benefit of early subtotal pancreatectomy.
    Author: Crowder WL, Maclaren NK, Gutberlet RL, Frost JL, Mason GR, Cornblath M.
    Journal: Pediatrics; 1976 Jun; 57(6):897-900. PubMed ID: 778772.
    Abstract:
    A newborn infant with pancreatic beta-cell hyperplasia had persistent hypoglycemia due to hyperinsulinism. After medical management, including the use of diazoxide and constant glucose infusions had proved ineffective, a subtotal pancreatectomy was curative. Cumulative experience seems to indicate that there should be little delay in performing a subtotal pancreatectomy when aggressive medical management cannot maintain normoglycemia in a neonate.
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