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  • Title: Adhesion to laminin is down-regulated upon retinoic acid-induced F9 cell differentiation: a role for alpha 6/beta 1 integrin.
    Author: Elias MC, Chammas R, Giorgi RR, Frochtengarten F, Santos CL, Brentani RR.
    Journal: Braz J Med Biol Res; 1994 Sep; 27(9):2181-4. PubMed ID: 7787801.
    Abstract:
    F9 mouse teratocarcinoma cells have a high capacity to adhere to laminin and we identified alpha 6/beta 1 integrin as the principal laminin-binding protein present in these cells. F9 cells differentiated into parietal endoderm when monolayer cultures were treated with retinoic acid and dibutyryl cyclic AMP. In this process a decreased adherence to laminin was observed due to a lower expression of alpha 6/beta 1 integrin on the cell surface.
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