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  • Title: [Relationship between levels of aspartate aminotransferase in gingival crevicular fluid and periodontal disease activity].
    Author: Yan F, Cao C, Li X.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 1995 Jan; 30(1):40-2, 64. PubMed ID: 7789235.
    Abstract:
    This paper describes a longitudinal study in which clinical parameters and aspartate aminotransferase (AST) in gingival crevicular fluid (GCF) were monitored bimonthly over a 6-12 months period in 970 sites from 7 treated periodontitis patients. In this study, 21 out of 970 sites exhibited new attachment loss (AL) of at least 2mm between two consecutive visits. The GCF-AST levels and clinical parameters at sites with active tissue destruction (> or = 2mm AL within two months) were significantly higher than those at control sites on the same tooth. The GCF-AST levels and clinical parameters at sites with active tissue destruction decreased significantly after re-treatment. The measurement of GCF-AST could be an useful adjunctive criterion for detection of disease activity. However, it seems to be unsatisfactory in predicting disease activity.
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