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  • Title: Co-trimoxazole and nitrofurantoin in urinary-tract infections: a controlled clinical study.
    Author: Lövestad A, Sabel G, Stefansson M, Gästrin B, Lundström R.
    Journal: Scand J Infect Dis Suppl; 1976; (8):58-60. PubMed ID: 779006.
    Abstract:
    The clinical efficacies of co-trimoxazole and nitrofurantoin were compared in patients with urinary-tract infections associated with significant bacteriuria with coliform bacteria tested and found to be sensitive to both drugs. Of 27 patients treated with co-trimoxazole, 23 were cured after 10 days' treatment with 320 mg trimethoprim and 1600 mg sulphamethoxazole daily (85%). Of 18 patients treated with nitrofurantoin (200 mg/day for 10 days), 7 were cured (39%). Thus, cotrimoxazole was significantly superior (p less than 0.01) in this study. A significant (p less than 0.001) but temporary and modest rise of the serum-creatinine levels was noted after 5 days' treatment with co-trimoxazole. Such a rise was not observed in the nitrofurantoin group. Only a few minor side effects were noted in both groups.
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