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  • Title: Slow Ca2+ waves in large myeloid cells as a result of a diffusible cytosolic factor.
    Author: Roberts GM, Davies EV, Hallett MB.
    Journal: J Leukoc Biol; 1995 Jun; 57(6):837-41. PubMed ID: 7790765.
    Abstract:
    In the work reported here evidence is provided that shows the slow wave of Ca2+ large neonatal myeloid cells provoked by formyl-Met-Leu-Phe was generated by spatially delayed Ca2+ influx. Evidence is provided that the delay in Ca2+ influx was the result of diffusion of a factor from the Ca2+ storage site, which is responsible for Ca2+ channel opening. The location of the Ca2+ release site was correlated with a region near the nucleus, probably a specialized region of endoplasmic reticulum. It is proposed that similar mechanisms of Ca2+ signaling occur in mature myeloid cells, such as neutrophils, but on a shorter time scale as a consequence of their smaller size.
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