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  • Title: Discrimination between panic disorder and generalized anxiety disorder by 35% carbon dioxide challenge.
    Author: Verburg K, Griez E, Meijer J, Pols H.
    Journal: Am J Psychiatry; 1995 Jul; 152(7):1081-3. PubMed ID: 7793449.
    Abstract:
    OBJECTIVE: The authors' goal was to determine whether 35% carbon dioxide (CO2) challenge would discriminate between patients with panic disorder and patients with other anxiety disorders. METHOD: Nine patients with panic disorder and nine with generalized anxiety disorder underwent the 35% CO2 challenge. RESULTS: Patients with panic disorder experienced a significantly stronger increase in subjective anxiety than patients with generalized anxiety disorder. However, increases in panic symptom scores were high in both groups. CONCLUSIONS: These results suggest that a large increase in subjective anxiety due to the CO2 challenge is specific for patients with panic disorder but that an increase in panic symptoms is not.
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