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  • Title: Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder.
    Author: Benjamin J, Levine J, Fux M, Aviv A, Levy D, Belmaker RH.
    Journal: Am J Psychiatry; 1995 Jul; 152(7):1084-6. PubMed ID: 7793450.
    Abstract:
    OBJECTIVE: Because they found in an earlier study that inositol, an important intracellular second-messenger precursor, was effective against depression in open and double-blind trials, the authors studied its effectiveness against panic disorder. METHOD: Twenty-one patients with panic disorder with or without agoraphobia completed a double-blind, placebo-controlled, 4-week, random-assignment crossover treatment trial of 12 g/day of inositol. RESULTS: The frequency and severity of panic attacks and the severity of agoraphobia declined significantly more after inositol than after placebo administration. Side effects were minimal. CONCLUSIONS: The authors conclude that inositol's efficacy, the absence of significant side effects, and the fact that inositol is a natural component of the human diet make it a potentially attractive therapeutic for panic disorder.
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