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  • Title: [Transdermal estradiol--the possibility for replacement therapy in the postmenopause].
    Author: Rachev E.
    Journal: Akush Ginekol (Sofiia); 1994; 33(3):45-7. PubMed ID: 7793531.
    Abstract:
    The author presents his experience in the treatment of 21 early postmenopausal women (mean age of 49.2 yrs) with transdermal delivery of 17 beta-oestradiol (Estraderm TTS, Ciba). During the treatment Kuppermann index falls from 28.5 to 10.9. Karyopyknotic index increases from 6.8 to 23.4 and maturation index moves from 39:52:9 to 0:71:29. Genital bleeding occurs in 52% of the patients. The author concludes that the treatment with transdermal delivery of oestradiol could be used more widely for replacement therapy in the postmenopause.
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