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  • Title: Prevention of iron loading in transfusion-dependent thalassaemia.
    Author: Pippard MJ, Letsky EA, Callender ST, Weatherall DJ.
    Journal: Lancet; 1978 Jun 03; 1(8075):1178-81. PubMed ID: 77945.
    Abstract:
    Urinary iron excretion after single intramuscular (i.m.) bolus injections or 12 h subcutaneous (s.c.) infusions of desferrioxamine (D.F.) was determined in sixteen homozygous beta-thalassaemia patients whose ages ranged from 10 months to 23 years. At all ages the s.c. infusions resulted in greater iron loss than identical i.m. doses. With doses of 0.5-1 g of D.F. as s.c. infusions eight out of nine children aged less than 6 years with a total transfusion iron load of less than 10 g excreted sufficient iron to achieve iron balance. These results suggest that iron loading in transfusion-dependent thalassaemics may be preventable by the use of an appropriate chelation regimen started early in life.
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