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  • Title: Upper and lower gastrointestinal complications with dexamethasone despite H2 antagonists.
    Author: McDonnell M, Evans N.
    Journal: J Paediatr Child Health; 1995 Apr; 31(2):152-4. PubMed ID: 7794619.
    Abstract:
    OBJECTIVE: To describe three preterm babies who developed gastrointestinal complications during treatment with dexamethasone for chronic lung disease, during a 10 month period. METHODOLOGY: Case reports in a tertiary neonatal intensive care unit. RESULTS: All three babies had received intravenous cimetidine since the commencement of steroid therapy, and developed gastrointestinal complications. There was no evidence of necrotizing enterocolitis in either of the two babies with gastrointestinal perforation. This is the first report of lower gastrointestinal complications associated with dexamethasone therapy. CONCLUSION: Recommendation of concomitant use of H2 antagonists with steroid therapy may be premature, and requires testing with a randomized controlled trial.
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