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  • Title: Effects of nasal continuous positive airway pressure on apnoea index and sleep in infants.
    Author: McNamara F, Harris MA, Sullivan CE.
    Journal: J Paediatr Child Health; 1995 Apr; 31(2):88-94. PubMed ID: 7794631.
    Abstract:
    OBJECTIVE: We examined the effectiveness of nasal continuous positive airway pressure (CPAP) for treatment of sleep apnoea in infants. METHODOLOGY: We studied five infants who all had significant central and mixed apnoea and severe sleep fragmentation. Polysomnographic recordings were performed on 2 consecutive nights in these infants. One night was used as a control study and during the second night nasal CPAP was applied throughout the night. RESULTS: Nasal CPAP significantly reduced apnoea in each infant, with the apnoea index (apnoeas/h) decreasing from 65.6 +/- 14.6 during the control study to 10.5 +/- 14.6 during CPAP in non-rapid eye movement (non-REM) sleep, and from 106 +/- 13.9 during the control study to 26.6 +/- 13.9 during CPAP in REM sleep. Nasal CPAP also improved the sleep fragmentation markedly; REM sleep increased from 14.2 +/- 1.2% of sleep during the control study to 27.1 +/- 1.2% of sleep during CPAP. CONCLUSIONS: We conclude that nasal CPAP is an effective treatment for infantile apnoea. Sleep apnoea in these infants is associated with profound sleep fragmentation, which is reversed by nasal CPAP.
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