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  • Title: Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars.
    Author: Schultze-Mosgau S, Schmelzeisen R, Frölich JC, Schmele H.
    Journal: J Oral Maxillofac Surg; 1995 Jan; 53(1):2-7; discussion 7-8. PubMed ID: 7799116.
    Abstract:
    PURPOSE: To test a combination treatment of ibuprofen and methylprednisolone for pain and swelling. METHODS: The efficacy of 32 mg methylprednisolone on pain and swelling when given 12 hours before and after surgery in combination with 400 mg ibuprofen three times a day given immediately on the day of the operation and on the two subsequent days following removal of impacted third molars was investigated in a placebo-controlled, intraindividual double-blind study. RESULTS: After use of ibuprofen/methylprednisolone, ultrasonic examination showed a reduction in swelling of 56% (P < .001) compared with the placebo group; measurement with a tape measure showed a 58% (P < .001) reduction in swelling. The visual analog scale showed a reduction of 67.7% in postoperative pain in comparison with placebo. CONCLUSION: The combination of ibuprofen and methylprednisolone has good analgesic and antiinflammatory action.
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