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  • Title: Combined effects of diltiazem and oxygen in pulmonary hypertension of mixed connective tissue disease.
    Author: Shinohara S, Murata I, Yamada H, Sato T, Kikutani T, Inoue T, Ito K.
    Journal: J Rheumatol; 1994 Sep; 21(9):1763-5. PubMed ID: 7799364.
    Abstract:
    A 45-year-old woman with pulmonary hypertension and mixed connective tissue disease (MCTD) underwent right heart catheterization to evaluate the effects of vasodilators. Nasal oxygen at 2 l/min in addition to 300 mg diltiazem improved pulmonary hemodynamics without adverse effects. After 1 year of diltiazem and home oxygen, sustained favorable hemodynamic effects were obtained, which were more marked than the acute effects. We conclude that this combination may be a potent treatment for pulmonary hypertension in patients with MCTD.
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