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  • Title: Sucrose malabsorption in man after ingestion of alpha-glucosidehydrolase inhibitor.
    Author: Caspary WF.
    Journal: Lancet; 1978 Jun 10; 1(8076):1231-3. PubMed ID: 77996.
    Abstract:
    The effect of an alpha-glucosidehydrolase inhibitor (alpha-G.H.I.) on intestinal absorption of sucrose was assessed by measuring rises in blood-glucose and intestinal hydrogen production after ingestion of 100 g sucrose. 200 mg alpha-G.H.I. given with the sucrose completely inhibited early postprandial blood-glucose rises, prevented late postprandial dips in blood-glucose, and considerably increased breath-hydrogen levels, which indicates sucrose malabsorption. Thus the inhibitor can be used to study carbohydrate malabsorption and may be useful as a method for retarding carbohydrate absorption.
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