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  • Title: Surgical implications of magnetic resonance-enhanced dura.
    Author: Ahmadi J, Hinton DR, Segall HD, Couldwell WT.
    Journal: Neurosurgery; 1994 Sep; 35(3):370-7;discussion 377. PubMed ID: 7800128.
    Abstract:
    The purpose of this study was to assess tissue changes responsible for dural enhancement of magnetic resonance imaging (MRI) and its clinical implications. A prospective surgical, histopathological, and MRI study was performed in 73 patients with various types of disease, including meningiomas (n = 29), craniofacial tumors with possible direct intracranial extension (n = 21), gliomas and brain metastasis in close proximity to the dura mater (n = 9), and a variety of nonneoplastic processes (n = 14). Contrast-enhanced MRI was obtained within 5 days before surgery and in some cases within 3 days after surgery as well. Histopathological examination of the dural specimens was performed in all 59 patients with neoplasia and in selected patients with nonneoplastic processes. Dural invasion was noted in 18 of 29 meningiomas, 15 of 21 craniofacial neoplasms, 3 of 5 gliomas, and 3 of 4 brain metastases. In these patients invasion was focal and in direct continuity with the tumors. MRI disclosed that dura invaded by the tumor had a break in the continuity of enhancement, or that there was no discernible enhancement. Association between patterns of dural enhancement and tumor invasion of dura was statistically significant (P < 0.001). The thickened-enhanced portion of the dura represented reactive changes. Postoperative enhancement was seen as early as 24 hours after surgery and was shown histologically to be associated with vasodilation and reactive changes.(ABSTRACT TRUNCATED AT 250 WORDS)
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