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  • Title: [Levels of endothelin-1 in bronchoalveolar lavage fluid of patients with bronchial asthma].
    Author: Gawlik R, Pluskiewicz W, Ziora D.
    Journal: Pol Arch Med Wewn; 1994 Aug; 92(2):117-22. PubMed ID: 7800579.
    Abstract:
    UNLABELLED: To evaluate the role of endothelin in the pathogenesis of bronchial asthma endothelin-1 levels were studied in the bronchoalveolar lavage fluid of symptomatic (n = 7) and asymptomatic (n = 10) asthmatic patients and healthy volunteers (n = 6). In all patients BAL fluid levels of endothelin-1 was assessed by RIA, total protein concentration by Lowry method. Patients with symptomatic asthma had increased amount of ET-1 in BAL fluid than asymptomatic asthmatics and control group. CONCLUSIONS: 1. Presence of endothelin in BAL fluid indicate that this peptide is involved in the pathogenesis of bronchial asthma. 2. Endothelin-1 BAL fluid levels may correlate with the severity of bronchial asthma.
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