These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of anti-progesterone compound RU486 on ovulation in immature mice treated with PMSG/hCG.
    Author: Kanayama K, Sankai T, Nariai K, Endo T, Sakuma Y.
    Journal: Res Exp Med (Berl); 1994; 194(4):217-20. PubMed ID: 7800930.
    Abstract:
    The effects of RU486, a competitive antagonist of progesterone, on ovulation were studied in PMSG/hCG-treated immature mice. PMSG/hCG was administered to 3-week-old female mice to induce ovulation. A dose of 0.5 mg of RU486 was administered 3 h before hCG injection, simultaneously with hCG injection, or 3, 4.5, 6, 7.5 or 9 h after hCG administration. The lowest number of ovulated eggs was observed in the group given RU486 6 h after hCG injection. Although the mean number of ovulated eggs was only 4.4 in this group, it was increased to 25.7 by supplementary administration of 2.0 mg of progesterone. It was demonstrated that RU486 had inhibitory effects on ovulation, and the inhibition could be prevented by supplementary administration of progesterone.
    [Abstract] [Full Text] [Related] [New Search]