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  • Title: [Home therapy approach in cancer patients-chemotherapy (case 2-2)].
    Author: Yamamura T.
    Journal: Gan To Kagaku Ryoho; 1994 Dec; 21 Suppl 4():554-6; discussion 557. PubMed ID: 7802464.
    Abstract:
    We have performed intra-arterial biochemical modulation chemotherapy of 5-FU with Leucovorin for patients with unresectable liver metastases from colorectal cancer. Three regimens were performed. A; weekly bolus injection of 5-FU and Leucovorin (6 cases), B; 7 days continuous injection of 5-FU after bolus injection of Leucovorin (4 cases), C; 5 days simultaneously continuous injection of 5-FU with Leucovorin (6 cases). The results were; response rate was A:0%, B:25%, C:33% and survival rate for patients of C method was better than that for patients of A and B method. Four patients complained mild nausea of less than Grade 2, but only one patient of C method. These results suggest that simultaneously continuous intra-arterial injection of 5-FU with Leucovorin is an excellent therapy for patients with unresectable liver metastases from colorectal cancer.
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