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  • Title: Comparison of DNA flow cytometric analysis of body cavity fluids with conventional cytology.
    Author: Lima CE, Mizushima Y, Masuda S, Kitagawa M.
    Journal: In Vivo; 1994; 8(3):359-62. PubMed ID: 7803718.
    Abstract:
    The potential utility of flow cytometric (FCM) analysis in routine diagnostic cytology for effusions was assessed with 104 samples from body cavity fluids. Conventional cytology showed no positivity (0/33) for effusions from patients with non-malignant diseases, and 45% positivity (38/71) for effusions from patients with malignant diseases. Conversely, FCM showed no positivity (aneuploid) (0/33) for effusions from patients with non-malignant diseases, and 18% positivity (13/71) with malignant diseases. In 13 cases examined, 8 cases (62%) showed an identical DNA ploidy pattern between effusion site and primary site. FCM showed positivity in four cytologically negative samples (3 malignant lymphomas and 1 clear cell carcinoma). In cases with malignant lymphoma, conventional cytology showed 40% positivity (4/10) and FCM 60% (6/10) positivity. These results indicate that DNA analysis of cells in malignant effusions does not have a diagnostic value as a routine test, but it may have in cases of malignant lymphoma.
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