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  • Title: Good's syndrome with a block in the early stage of B cell differentiation and complicated by Campylobacter fetus sepsis.
    Author: Yamazaki K, Watanabe N, Hasegawa A, Yamaguchi E, Miyamoto K, Sakiyama Y, Kawakami Y.
    Journal: Intern Med; 1994 Aug; 33(8):496-500. PubMed ID: 7803919.
    Abstract:
    A 63-year-old man was admitted for Campylobacter fetus sepsis and immunodeficiency syndrome with thymoma (Good's syndrome). Serological examination demonstrated hypoimmunoglobulinemia. Analysis of lymphocyte subsets in the peripheral blood and bone marrow showed marked decreases in the proportion of cells bearing B cell markers. However, there were no abnormalities of cellular immunity. This is a rare case of Good's syndrome in Japan in which the pathogenic mechanism involved a block in the early stage of B cell differentiation. Moreover, this is the first case ever reported of Campylobacter fetus sepsis associated with Good's syndrome.
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