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  • Title: Determination of the normal range of furosemide half-clearance times when using Tc-99m MAG3.
    Author: Rossleigh MA, Thomas MY, Moase AL.
    Journal: Clin Nucl Med; 1994 Oct; 19(10):880-2. PubMed ID: 7805322.
    Abstract:
    In radionuclide diuresis renography, furosemide half-clearance times have been established using Tc-99m DTPA but have not been verified when Tc-99m MAG3 is used. One hundred and six consecutive diuretic renograms using Tc-99m MAG3 for the evaluation of unilateral renal abnormalities were assessed. The furosemide half-clearance times of the normal kidneys were all less than 9.8 minutes, with a mean of 3.4 minutes. In 18 patients, the half-clearance times of the normal kidney were artificially prolonged because urine had drained before the administration of the diuretic. The normal furosemide half-clearance time values obtained using Tc-99m MAG3 were found to be similar to those established for Tc-99m DTPA. Prolonged half-clearance times of Tc-99m MAG3 must be confirmed by visual evidence of obstruction.
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