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  • Title: FCCP modulation of Ca2+ oscillation in rat megakaryocytes.
    Author: Uneyama C, Uneyama H, Takahashi M, Akaike N.
    Journal: Eur J Pharmacol; 1994 Aug 16; 268(3):455-8. PubMed ID: 7805773.
    Abstract:
    The effects of a mitochondrial uncoupler, FCCP, (carbonyl cyanide-p-trifluromethoxyphenyl-hydrazone) on the regulation of cytoplasmic Ca2+ were investigated in ATP-induced Ca2+ oscillation system of rat megakaryocyte. Application of FCCP did not induce any detectable Ca(2+)-activated K+ current (IKCa) but pretreatment with FCCP modulated the ATP-induced repetitive IKCa. FCCP abolished the IKCa induced by low concentrations of ATP. However, when the concentration of ATP was high, the uncoupler also changed the periodic current to a sustained one. Similar biphasic regulation by the uncoupler was observed in the case of IP3-evoked repetitive IKCa. These results indicate that FCCP inhibits both Ca2+ mobilization and elimination processes after IP3 liberation induced by agonist stimulation.
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