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  • Title: Development of anti-human B blood group monoclonal antibodies suitable as a blood typing reagent.
    Author: Becker MI, Juica F, Jamett A, Tzichinovsky S, Barros S, Aguayo J, De Ioannes AE.
    Journal: Hybridoma; 1994 Aug; 13(4):303-10. PubMed ID: 7806251.
    Abstract:
    An improved procedure for the generation of high-avidity anti-human B blood group monoclonal antibodies (MAbs) was developed. One of them, termed 7A1-2, showed excellent qualities of titer, avidity, and intensity required for use as human B blood typing reagent. Hemagglutination inhibition studies with monosaccharides and oligosaccharides were carried out to determine the specificity of the MAb 7A1-2. These studies indicate that the antibody reacts with the immunodominant region of the antigen which is known to confer the serologic specificity of this blood group.
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