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  • Title: Retinoblastoma.
    Author: Lueder GT, Smith ME.
    Journal: Semin Diagn Pathol; 1994 May; 11(2):104-6. PubMed ID: 7809503.
    Abstract:
    Retinoblastoma (RB) is the most common intraocular malignancy of childhood, occurring in approximately 1 in 20,000 live births. It arises from pluripotential retinal progenitor cells. Mutations of the RB1 gene interfere with regulation of the cell cycle. Patients who harbor a germinal mutation of the RB1 gene are at risk for the development of second, non-ocular tumors.
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