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  • Title: [The plasticity of the snail cholinoreceptor neurons following exposures to the inositol 1,4,5-triphosphate- and Ca2(+)-dependent mobilization of deposited Ca2(+) and the level of phosphatidic acid].
    Author: Pivovarov AS.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1994; 44(4-5):796-805. PubMed ID: 7810221.
    Abstract:
    Effects of some substances (which influence on mobilization of deported Ca2+ and intracellular level of second messengers) on identified neurons RPa3 and LPa3 of Helix lucorum were studied using two-electrode voltage clamp technique. The action of inositol-1,4,5-trisphosphate (IP3), inositolhexakisphosphate (IP6), TMB-8 inhibitor of IP3-dependent Ca2+ mobilization), tetracaine (inhibitor of Ca(2+)-dependent mobilization of Ca2+), and phospholipase D (which catalyzes phosphatidic acid formation from membrane phosphatidylcholine) was studied. Participation of IP3, IP3-dependent-, Ca(2+)-dependent mobilized intracellular Ca2+ and phosphatidic acid in regulation of cholinoreceptor plasticity was shown in Helix neurons.
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